Software that really works! Comic Life2 by Plasq

Comic Life 2 by Plasq is very easy to use and create a PDF or JPG file as exported output. There are both pre-configured frames and blank pages that can be customized. Drag the photo or clip from the internet right onto the Comic Life page. Bingo! That's it.

There are pre-configured labels and balloons/bubbles for commentary. Use the top row of tabs to get "insert" and then "shape" for customized arrows and lines. Click on the "shape" to edit the high-lighted vertices in the shape's features. Just save those shapes to a dedicated file and future editing will be a snap.

There are versions for the Mac and Windows machines. The Mac version has the most up-to-date usability, of course.

Support assistance is responsive and actually handled by a helpful member of the human race. Another good feature.